Scott Douglas "Scooter" Altman is a retired United States Navy Captain, engineer, test pilot and former NASA astronaut. He is a veteran of four Space Shuttle missions. His fourth mission on STS-125 was the last servicing mission to the Hubble Space Telescope.

Jeffrey Shears "Bones" Ashby is an American mechanical engineer, and former naval officer and aviator, test pilot and NASA astronaut, a veteran of three Space Shuttle missions. He is a retired Captain in the U.S. Navy. He currently works for Blue Origin as chief of mission assurance.

Michael John "Bloomer" Bloomfield is an American former astronaut and a veteran of three Space Shuttle missions.

Joe Frank Edwards Jr. is an American aerospace engineer, and former naval officer and aviator, test pilot and NASA astronaut.

Dominic Lee Pudwill Gorie is a retired United States Navy officer and NASA astronaut. He is a veteran of four space shuttle missions.

Steven Wayne Lindsey is a retired U.S. Air Force officer and NASA astronaut. Lindsey served as Chief of the NASA Astronaut Office from September 2006 until October 2009.

Pamela Anne Melroy is a retired United States Air Force officer and a former NASA astronaut. She served as pilot on Space Shuttle missions STS-92 and STS-112 and commanded mission STS-120 before leaving the agency in August 2009. After serving as Deputy Program Manager, Space Exploration Initiatives with Lockheed Martin, Melroy joined the Federal Aviation Administration in 2011, where she was a senior technical advisor and director of field operations for the FAA's Office of Commercial Space Transportation. In 2013, she left the FAA and joined DARPA as Deputy Director of the Tactical Technology Office. She left the agency in February, 2017.

Susan Kilrain is an engineer, a former United States Navy officer, and a former NASA astronaut.

Frederick Wilford "Rick" Sturckow is an Engineer, retired United States Marine Corps officer, former NASA astronaut, and commercial spacecraft pilot. Sturckow is a veteran of four Space Shuttle missions. He flew on STS-88 and STS-105 as a pilot and STS-117 and STS-128 as a commander. All four missions docked with the International Space Station, making Sturckow one of two people to visit the station four times. Sturckow later was assigned to the Johnson Space Center as a CAPCOM. He left NASA in 2013 to become a pilot for Virgin Galactic.

Michael Phillip Anderson was a United States Air Force officer and NASA astronaut. Anderson and his six fellow crew members were killed in the Space Shuttle Columbia disaster when the craft disintegrated during its re-entry into the Earth's atmosphere. Anderson served as the payload commander and lieutenant colonel in charge of science experiments on the Columbia. Anderson was posthumously awarded the Congressional Space Medal of Honor.

Kalpana Chawla was an American astronaut and the first female of Indian origin to go to space. She first flew on Space Shuttle Columbia in 1997 as a mission specialist and primary robotic arm operator. In 2003, Chawla was one of the seven crew members who died in the Space Shuttle Columbia disaster when the craft disintegrated during its re-entry into the Earth's atmosphere. Chawla was posthumously awarded the Congressional Space Medal of Honor, and several streets, universities and institutions have been named in her honor.

Robert Lee Curbeam, Jr. is a former NASA astronaut and captain in the United States Navy. Curbeam graduated from Woodlawn High School, Baltimore County, Maryland in 1980. He earned a Bachelor of Science degree in Aerospace Engineering from the United States Naval Academy in 1984, a Master of Science degree in Aeronautical Engineering from the Naval Postgraduate School in 1990, and a master's degree in Astronautical Engineering from the Naval Postgraduate School in 1991. He is a member of the U.S. Naval Academy Alumni Association and the Association of Old Crows. Curbeam was named Fighter Wing One Radar Intercept Officer of the Year in 1989 and received the U.S. Naval Test Pilot School Best Developmental Thesis (DT-II) Award. He currently holds the record for the most spacewalks during a single spaceflight. During the STS-116 mission, Curbeam completed four spacewalks.