Sharon Christa McAuliffe (born Sharon Christa Corrigan; September 2, 1948 – January 28, 1986) was an American teacher and astronaut from Concord, New Hampshire and one of the seven crew members killed in the Space Shuttle Challenger disaster.

Samuel Thornton Durrance (Ph.D.) was an American scientist who flew aboard two NASA Space Shuttle missions as a payload specialist.

Ronald Anthony Parise (May 24, 1951 – May 9, 2008) was an Italian American scientist who flew aboard two NASA Space Shuttle missions as a payload specialist.

Jerome "Jay" Apt III, Ph.D. (born April 28, 1949 in Massachusetts) is an American astronaut and professor at Carnegie Mellon University. Before he became an astronaut, Apt was a physicist who worked on the Pioneer Venus 1978 space probe project, and used visible light and infrared techniques to study the planets and moons of the solar system from ground-based observatories.

Francis Andrew "Drew" Gaffney is an American doctor. He previously worked for NASA and participated in the STS-40 Space Life Sciences (SLS 1) Space Shuttle mission in 1991 as a payload specialist. The SLS-1 mission crew completed over 18 experiments in nine days, bringing back more medical data than any previous NASA flight. He is currently a professor of medicine at Vanderbilt University.

Millie Elizabeth Hughes-Fulford was an American medical investigator, molecular biologist and former NASA astronaut who flew aboard a NASA Space Shuttle mission as a Payload Specialist.

Lawrence James "Larry" DeLucas (O. D., Ph.D.) is an American biochemist who flew aboard NASA Space Shuttle mission STS-50 as a Payload Specialist. DeLucas was a member of the crew of Space Shuttle Columbia for STS-50 (June 25-July 9, 1992), the United States Microgravity Laboratory-1 (USML-1) Spacelab mission. Over a two-week period, the crew conducted a wide variety of experiments relating to materials processing and fluid physics. At mission conclusion, DeLucas had traveled over 5.7 million miles in 221 Earth orbits, and had logged over 331 hours in space.

Eugene Huu-Chau "Gene" Trinh (Vietnamese: Trịnh Hữu Châu, born September 14, 1950) is a Vietnamese American biochemist who flew aboard NASA Space Shuttle mission STS-50 as a Payload Specialist, becoming the first Vietnamese American astronaut in space.

Martin Joseph Fettman (B.S., D.V.M., M.S., Ph.D., Diplomate, ACVP) is an American pathologist and researcher who flew on NASA Space Shuttle mission STS-58 aboard the Space Shuttle Columbia as a Payload Specialist.

Fred Weldon Leslie is an American scientist who flew on the NASA STS-73 Space Shuttle mission as a payload specialist.

Albert Sacco Jr. (born May 3, 1949) is an American chemical engineer who flew as a Payload Specialist on the Space Shuttle Columbia on shuttle mission STS-73 in 1995.

Roger Keith Crouch (born September 12, 1940) is an American scientist and astronaut who flew as a payload specialist on two NASA Space Shuttle missions in 1997.